VIB spin-off Flamingo Therapeutics merges with Dynacure to create leading RNA therapeutics company in oncology

The combined company will continue under the name Flamingo Therapeutics

VIB spin-off Flamingo Therapeutics and Dynacure announced today that both companies have signed a definitive merger agreement. The combined company will continue under the name Flamingo Therapeutics and will further pursue their positioning as a single leading RNA therapeutics company in oncology. Additionally, current investors Kurma Partners and PMV have made a further investment in the company.

Flamingo Therapeutics is a VIB spin-off company that was originally founded in 2020 based on pioneering work by Jean-Christophe Marine (VIB-KU Leuven Center for Cancer Biology) and Pieter Mestdagh (CRIG) in the field of lncRNAs. Bringing together Flamingo Therapeutics's and Dynacure’s expertise, the combined company will advance Flamingo’s lead programs. 

The first program which Flamingo Therapeutics will continue to advance is Danvatirsen, an antisense oligonucleotide (ASO) that selectively targets STAT3 and has shown clinical activity in Phase II clinical studies. The therapeutic effect of STAT3 suppression results in reduction of tumor cell growth as well as activation of anti-tumor immunity mediated by the tumor micro-environment. Currently, Danvatirsen is planned to continue Phase II clinical development for head and neck squamous cell carcinoma to advance the program through key clinical milestones and data readouts. 

In addition, the combined company will also advance FTX-001, Flamingo’s most advanced LncRNA program which targets MALAT-1, through readiness for Phase I in solid tumors. LncRNA has been dubbed the dark matter of the human genome because not much is known about it. However, it proves to be a large class of innovative therapeutic targets. 

Stephane van Rooijen, CEO of Flamingo Therapeutics: “The merger of Flamingo and Dynacure is a great strategic fit for both companies, leveraging a wealth of RNA therapeutic expertise and cancer drug development, and combining teams to create a stronger organization. With our well-defined clinical strategy and operational plan, we are focused on creating value for all stakeholders, including patients, clinicians and our investors. We plan to continue to execute upon our clinical strategy with the combined company and team in place.”
Lies Vanneste

Lies Vanneste

Investor Relations Manager, VIB

Share

Latest stories

Website preview
MRM Health Raises €55 Million Series B to Advance Best-in-Class Microbiome-based Biotherapeutic Product Pipeline
Ghent, Belgium – September 04, 2025 – MRM Health NV, a clinical-stage biopharmaceutical company pioneering microbiome-based therapeutics for inflammatory diseases and immune-oncology, today announced the successful closing of a €55 million (US$64 million) Series B financing round.
press.vib.be
Website preview
Spica Therapeutics Secures €1 Million VLAIO Grant to Advance Groundbreaking Macrophage-Targeted Cancer Therapy
Antwerp, Belgium - 27 August, 2025 - Spica Therapeutics, a pioneering biotech company focused on harnessing macrophage biology to develop transformative therapies across multiple disease areas, announced today that it has been awarded a €1.0 million grant from Flanders Innovation & Entrepreneurship (VLAIO).
press.vib.be
Website preview
Scientists map dendritic cell reactions to vaccines 
Ghent, 26 August 2025 – Belgian scientists have uncovered new details about how the immune system responds to vaccines. Dendritic cells, which are key immune messengers that help kick-start the body’s defenses, show specific responses to lipid nanoparticles. These findings, published in Cell Reports, could lead to safer and more effective vaccines.  
press.vib.be

About VIB Press

VIB is an independent research institute that translates insights in biology into impactful innovations for society. Collaborating with the five Flemish universities, it conducts research in plant biology, cancer, neuroscience, microbiology, inflammatory diseases, artificial intelligence and more. VIB connects science with entrepreneurship and stimulates the growth of the Flemish biotech ecosystem. The institute contributes to solutions for societal challenges such as new methods for diagnostics and treatments, as well as innovations for agriculture. 

Learn more at www.vib.be.

Contact

Suzanne Tassierstraat 1 9052 Zwijnaarde

+32 9 244 66 11

press@vib.be

vib.be