Structural Biology
New lung cancer model reveals how tumor location shapes the immune response
Brussels, 27 April 2026 – Researchers at VIB and VUB have developed a powerful new way to study how the immune system behaves inside lung tumors. By combining a patient-relevant mouse model with single-cell technologies, the team provides one of the most comprehensive immune maps to date of lung adenocarcinoma, which is the most common subtype of lung cancer. Their work appears in Nature Communications.
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Designing better membrane proteins by embracing imperfection
Brussels, 14 April 2026 — Scientists at the VIB–VUB Center for Structural Biology have uncovered a counterintuitive principle that could reshape how membrane proteins are designed from scratch: sometimes, making a protein less stable helps it fold correctly. In a study published in Proceedings of the National Academy of Sciences (PNAS), researchers demonstrate that introducing carefully placed ‘imperfections’, a strategy known as negative design, enables synthetic membrane proteins to fold and assemble efficiently in artificial membranes.
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