Cancer Biology
What causes cancer and how can we find better ways to treat it?
![Researchers identify a key metabolic gene as target for improved cancer immunotherapy](https://cdn.uc.assets.prezly.com/61e85912-0631-49b7-a125-8cd999d7cb29/-/crop/2010x1288/0,503/-/preview/-/format/jpeg/-/stretch/off/-/progressive/yes/-/resize/3840x/-/quality/smart/Pancreas.jpg)
Researchers identify a key metabolic gene as target for improved cancer immunotherapy
The CDA gene is among the top upregulated metabolic genes in immunotherapy-resistant tumors
June 6, 2024
![Researchers map cell composition of metastatic melanoma and identify cause of immunotherapy resistance](https://cdn.uc.assets.prezly.com/e4776872-80b7-4a73-a466-217fb6d14802/-/crop/1579x612/0,470/-/preview/-/format/jpeg/-/stretch/off/-/progressive/yes/-/resize/3840x/-/quality/smart/PHOTO-2022-10-13-17-47-04-1.jpg)
Researchers map cell composition of metastatic melanoma and identify cause of immunotherapy resistance
Targeting mesenchymal-like melanoma cells could instigate immunotherapy response
January 9, 2024
![Disabling autophagy can enhance immune response in melanoma](https://cdn.uc.assets.prezly.com/5265a91c-8ee5-46f0-a920-1043aded5869/-/crop/1038x416/0,71/-/preview/-/format/auto/-/stretch/off/-/progressive/yes/-/resize/3000x/-/quality/smart/Melanoma-TEC.png)
Disabling autophagy can enhance immune response in melanoma
Researchers discover that disabling autophagy in Tumor Endothelial Cells, inflames them and leads to a better immune response
November 28, 2023
![Researchers discover cause of immunosuppressive behavior of regulatory T cells in cancer](https://cdn.uc.assets.prezly.com/940d9764-a68b-4ed4-ade0-88048444afb5/-/crop/3200x1524/0,786/-/preview/-/format/jpeg/-/stretch/off/-/progressive/yes/-/resize/3840x/-/quality/smart/Tumor%20cells.jpg)
Researchers discover cause of immunosuppressive behavior of regulatory T cells in cancer
Fucosylation – the addition of a fucose sugar to a molecule – has been identified as the driving force behind unbalanced Treg behavior in tumor microenvironment
November 13, 2023
![New research shows insights into devastating metabolic disease](https://cdn.uc.assets.prezly.com/41fb9bd3-e306-42f4-a1c5-f52cd813f2d3/-/crop/2844x684/0,0/-/preview/-/format/jpeg/-/stretch/off/-/progressive/yes/-/resize/3840x/-/quality/smart/Protein%20or%20Enzyme.jpg)
New research shows insights into devastating metabolic disease
Tracer metabolomics reveals the role of aldose reductase in glycosylation
June 5, 2023
![Precursor of breast cancer or not?](https://cdn.uc.assets.prezly.com/c671d37f-5b3c-4af0-8b7a-c48c4eccab6a/-/format/jpeg/-/stretch/off/-/progressive/yes/-/resize/3840x/-/quality/smart/20230502_141_R2.jpg)
Precursor of breast cancer or not?
New mouse model bridges 10-20 years of development of DCIS into breast cancer within one year
May 2, 2023
![Reinforcing endothelial TRAIL protects against cancer metastasis](https://cdn.uc.assets.prezly.com/03feae0c-2b8b-4a6d-9867-9575e645a90d/-/crop/986x283/0,319/-/preview/-/format/jpeg/-/stretch/off/-/progressive/yes/-/resize/3840x/-/quality/smart/Endothelial%20cells%20in%20vitro%20-%20dapi%20blue%20%2B%20Ki67%20magenta%20%2B%20TRAIL%20green%20-%20to%20send.jpg)
Reinforcing endothelial TRAIL protects against cancer metastasis
TRAIL proteins function as gatekeepers for vascular barrier integrity and blocks entry of cancer cells to metastatic sites
March 23, 2023
![Fat creates an ideal environment for metastatic breast tumors](https://cdn.uc.assets.prezly.com/dcef5957-b8f7-4226-8702-79fa9e98b35d/-/format/jpeg/-/stretch/off/-/progressive/yes/-/resize/3840x/-/quality/smart/Palmitate_SMF_PAM.jpg)
Fat creates an ideal environment for metastatic breast tumors
Palmitate can initiate a series of signals in cancer cells that equip them to grow into metastases.
February 3, 2023
![Targeting acidity: a new approach to tackle pancreatic cancer](https://cdn.uc.assets.prezly.com/5b9b13a1-c9b2-4855-9e4b-99368e8602c3/-/crop/1280x489/0,222/-/preview/-/format/auto/-/stretch/off/-/progressive/yes/-/resize/3000x/-/quality/smart/Increased%20cancer%20cell%20killing%20mediated%20by%20T%20cells%20after%20Slc4a4%20targeting.png)
Targeting acidity: a new approach to tackle pancreatic cancer
Inhibiting the bicarbonate transporter SLC4A4 in pancreatic cancer cells promotes an immune reaction and supports immunotherapy effectiveness.
December 15, 2022
![VIB researchers identify a new way of supporting and sensitizing immunotherapy in cancer patients](https://cdn.uc.assets.prezly.com/a972a0df-6f5f-4010-a556-a916ebb8fd60/-/format/jpeg/-/stretch/off/-/progressive/yes/-/resize/3840x/-/quality/smart/HEV-IC%20image.jpg)
VIB researchers identify a new way of supporting and sensitizing immunotherapy in cancer patients
Therapeutic induction of High-Endothelial Venules (HEV) can augment lymphocyte infiltration and contributes to tumor growth inhibition
November 24, 2022
![Enhancing the way immune cells respond to a threat](https://cdn.uc.assets.prezly.com/d9722e65-ab81-4fe6-ba36-0c70d94a25c6/-/crop/1750x724/58,0/-/preview/-/format/auto/-/stretch/off/-/progressive/yes/-/resize/3000x/-/quality/smart/FACS_ActivationEvolution.png)
Enhancing the way immune cells respond to a threat
VIB researchers uncover a metabolic switch that allows immune cells to enhance their protective function.
November 17, 2022
![Researchers identify which cancer cell subpopulations cause tumor growth and metastasis](https://cdn.uc.assets.prezly.com/c6513376-8c6b-464b-b8c3-c0a33c6778f1/-/format/auto/-/stretch/off/-/progressive/yes/-/resize/3000x/-/quality/smart/Image%202_press_clones.png)
Researchers identify which cancer cell subpopulations cause tumor growth and metastasis
New discoveries open new avenues for the prevention of early tumor growth and metastatic dissemination
September 22, 2022